Methodologies to Increase the Level of Evidence of Real-life Proton Therapy in Head and Neck Tumors

Francesco Dionisi, MD; Lamberto Widesott, PhD; Van VulpenMarco, MD; Clifton David Fuller, MD; Rocco Frondizi, PhD; Marco Meneguzzo; Pierre Blanchard, MD; Maurizio Amichetti, MD; Giuseppe Sanguineti, MD

doi:10.14338/IJPT-20-00051.1

International Journal of Particle Therapy (Jun 2021)

Methodologies to Increase the Level of Evidence of Real-life Proton Therapy in Head and Neck Tumors

Francesco Dionisi, MD,
Lamberto Widesott, PhD,
Van VulpenMarco, MD,
Clifton David Fuller, MD,
Rocco Frondizi, PhD,
Marco Meneguzzo,
Pierre Blanchard, MD,
Maurizio Amichetti, MD,
Giuseppe Sanguineti, MD

Affiliations

Francesco Dionisi, MD: 1 Proton Therapy Unit, Department of Oncology, Azienda Provinciale per I Servizi Sanitari (APSS), Trento, Italy
Lamberto Widesott, PhD: 1 Proton Therapy Unit, Department of Oncology, Azienda Provinciale per I Servizi Sanitari (APSS), Trento, Italy
Van VulpenMarco, MD: 3 Proton Therapy Center, Delft, the Netherlands
Clifton David Fuller, MD: 4 Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
Rocco Frondizi, PhD: 5 Department of Management and Law, Tor Vergata University of Rome, Rome, Italy
Marco Meneguzzo: 5 Department of Management and Law, Tor Vergata University of Rome, Rome, Italy
Pierre Blanchard, MD: 7 Department of Radiation Oncology, Gustave Roussy Cancer Campus, Villejuif, France
Maurizio Amichetti, MD: 1 Proton Therapy Unit, Department of Oncology, Azienda Provinciale per I Servizi Sanitari (APSS), Trento, Italy
Giuseppe Sanguineti, MD: 2 Department of Radiation Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Regina Elena National Cancer Institute, Rome, Italy

DOI: https://doi.org/10.14338/IJPT-20-00051.1
Journal volume & issue: Vol. 8, no. 1
pp. 328 – 338

Abstract

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This review aims to present and assess available and new methodologies to increase the clinical evidence of proton therapy data for patients with head and neck cancer. Despite the increasing number of scientific reports showing the feasibility and effectiveness of proton therapy in head and neck cancer, clinical evidence on the potential benefits of its use remains low for several reasons. In this article, the pros and cons of consolidated and new methodologies in this setting such as randomized clinical trials, the model-based approach, and the use of prospective multicentric registries will be detailed.

Published in International Journal of Particle Therapy

ISSN: 2331-5180 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine; Science: Physics: Nuclear and particle physics. Atomic energy. Radioactivity
Website: https://www.sciencedirect.com/journal/international-journal-of-particle-therapy

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