Journal of Rawalpindi Medical College (Dec 2012)
Effect of Pro-Kinetic Drugs on Post –Prandial Glycaemic Surge in Type 2 Diabetic Patients
Abstract
Background: To study the effects of pro-kinetic agents on post-prandial glycaemia in type 2 diabetes mellitus. Methods :In this comparative study one hundred and eighty patients with Type 2 diabetes mellitus and features of gastroparesis were randomly recruited. They were divided randomly into two groups of ninety each.Group I was given oral antidiabetic agents and placebo. Group II was given oral anti-diabetic agents along with domperidone. Mean levels of glycaemic difference. Difference between Premeal and two hours postmeal and glycaemic levels were determined and compared in the two groups. Results :Mean fasting blood sugar of Group I was 168.57 mg/dl and 2 hours postprandial was 296.73 mg/dl. In Group II mean fasting blood sugar was 201.24 mg/dl and mean 2 hours postprandial blood sugar was 296.42 mg/dl. Mean difference in fasting and 2 hours post prandial was 156.38 mg/dl and 114.15 mg/dl, respectively in Group I and II. Conclusion: Mean difference between fasting and 2 hours postprandial blood sugar is significantly low in patients taking prokinetic drugs, as compared to the diabetics not taking pro-kinetic drugs.
