Clinical and neurophysiological studies of chronic demyelinating polyneuropathy associated with monoclonal secretion

Abstract

Paraproteinemic polyneuropathy accounts for up to 30% of chronic demyelinating polyneuropathies. The aim of this study was to determine the clinical and neurophysiological patterns of the nosology compared with chronic inflammatory demyelinating polyneuropathy (CIDP). We examined 30 patients with PNP against a background of monoclonal gammopathy (16 with monoclonal gammopathy of undetermined significance (MGUS) and 14 with hemoblastosis) and 30 patients with CIDP. The history, neurological status and results of stimulation electroneuromyography were evaluated. A number of significant differences were recorded which suggest paraproteinemia in patients with demyelinating PNP. Nevertheless, immunofixation electrophoresis is currently the only method of the disease verification.

Keywords

• хроническая демиелинизирующая полиневропатия
• парапротеинемия
• моноклональная секреция
• электрофорез сыворотки с иммунофиксацией
• электронейромиография
• chronic demyelinating polyneuropathy
• paraproteinemia
• monoclonal secretion
• immunofixation electropho