Nature Communications (Mar 2021)
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition
- Peter J. Mullen,
- Gustavo Garcia,
- Arunima Purkayastha,
- Nedas Matulionis,
- Ernst W. Schmid,
- Milica Momcilovic,
- Chandani Sen,
- Justin Langerman,
- Arunachalam Ramaiah,
- David B. Shackelford,
- Robert Damoiseaux,
- Samuel W. French,
- Kathrin Plath,
- Brigitte N. Gomperts,
- Vaithilingaraja Arumugaswami,
- Heather R. Christofk
Affiliations
- Peter J. Mullen
- Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA)
- Gustavo Garcia
- Department of Molecular and Medical Pharmacology, UCLA
- Arunima Purkayastha
- UCLA Children’s Discovery and Innovation Institute, Mattel Children’s Hospital UCLA, Department of Pediatrics, David Geffen School of Medicine, UCLA
- Nedas Matulionis
- Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA)
- Ernst W. Schmid
- Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA)
- Milica Momcilovic
- Department of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, UCLA
- Chandani Sen
- UCLA Children’s Discovery and Innovation Institute, Mattel Children’s Hospital UCLA, Department of Pediatrics, David Geffen School of Medicine, UCLA
- Justin Langerman
- Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA)
- Arunachalam Ramaiah
- Department of Ecology and Evolutionary Biology, University of California, Irvine
- David B. Shackelford
- Department of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, UCLA
- Robert Damoiseaux
- Department of Molecular and Medical Pharmacology, UCLA
- Samuel W. French
- Jonsson Comprehensive Cancer Center, UCLA
- Kathrin Plath
- Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA)
- Brigitte N. Gomperts
- UCLA Children’s Discovery and Innovation Institute, Mattel Children’s Hospital UCLA, Department of Pediatrics, David Geffen School of Medicine, UCLA
- Vaithilingaraja Arumugaswami
- Department of Molecular and Medical Pharmacology, UCLA
- Heather R. Christofk
- Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA)
- DOI
- https://doi.org/10.1038/s41467-021-22166-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
The pandemic of COVID-19, caused by SARS-CoV-2 infection, warrants immediate investigation for therapy options. Here the authors show, using epithelial and air-liquid interface cultures, that SARS-CoV-2 hijacks host cell metabolism to facilitate viral replication, and that inhibition of mTORC1, a master metabolic regulator, suppresses viral replication.
