European Journal of Hybrid Imaging (Apr 2023)

Quantitative assessment of PSMA PET response to therapy in castration-sensitive prostate cancer using an automated imaging platform for disease identification and measurement

  • Sai Duriseti,
  • Gholam Berenji,
  • Sonny Tsai,
  • Matthew Rettig,
  • Nicholas G. Nickols

DOI
https://doi.org/10.1186/s41824-023-00165-6
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 9

Abstract

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Abstract Rationale Prostate cancer treatment response may be automatically quantified using a molecular imaging analysis platform targeting prostate-specific membrane antigen (PSMA). Methods A retrospective analysis of patients with castration-sensitive prostate cancer who underwent PSMA-targeted molecular imaging prior to and 3 months or more after treatment was conducted. Disease burden was analyzed with aPROMISE, an artificial intelligence imaging platform that automatically quantifies PSMA-positive lesions. The calculated PSMA scores for prostate/bed, nodal, and osseous disease sites were compared with prostate-specific antigen (PSA) values. Results Of 30 eligible patients, the median decline in prostate/bed, nodal, and osseous disease PSMA scores were 100% (range 52–100%), 100% (range − 87–100%), and 100% (range − 21–100%), respectively. PSMA score decline was significantly associated with PSA decline. Conclusion Changes in aPROMISE PSMA scores are associated with changes in PSA and may quantify treatment response.

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