Nature Communications (Apr 2022)
Zoonotic origin of the human malaria parasite Plasmodium malariae from African apes
- Lindsey J. Plenderleith,
- Weimin Liu,
- Yingying Li,
- Dorothy E. Loy,
- Ewan Mollison,
- Jesse Connell,
- Ahidjo Ayouba,
- Amandine Esteban,
- Martine Peeters,
- Crickette M. Sanz,
- David B. Morgan,
- Nathan D. Wolfe,
- Markus Ulrich,
- Andreas Sachse,
- Sébastien Calvignac-Spencer,
- Fabian H. Leendertz,
- George M. Shaw,
- Beatrice H. Hahn,
- Paul M. Sharp
Affiliations
- Lindsey J. Plenderleith
- Institute of Evolutionary Biology and Centre for Immunity, Infection and Evolution, University of Edinburgh
- Weimin Liu
- Department of Medicine, University of Pennsylvania
- Yingying Li
- Department of Medicine, University of Pennsylvania
- Dorothy E. Loy
- Department of Medicine, University of Pennsylvania
- Ewan Mollison
- Institute of Evolutionary Biology and Centre for Immunity, Infection and Evolution, University of Edinburgh
- Jesse Connell
- Department of Medicine, University of Pennsylvania
- Ahidjo Ayouba
- Recherche Translationnelle Appliquée au VIH et aux Maladies Infectieuses, Institut de Recherche pour le Développement, University of Montpellier, INSERM
- Amandine Esteban
- Recherche Translationnelle Appliquée au VIH et aux Maladies Infectieuses, Institut de Recherche pour le Développement, University of Montpellier, INSERM
- Martine Peeters
- Recherche Translationnelle Appliquée au VIH et aux Maladies Infectieuses, Institut de Recherche pour le Développement, University of Montpellier, INSERM
- Crickette M. Sanz
- Department of Anthropology, Washington University in St. Louis
- David B. Morgan
- Wildlife Conservation Society, Congo Program, BP
- Nathan D. Wolfe
- Metabiota Inc
- Markus Ulrich
- Robert Koch Institute
- Andreas Sachse
- Robert Koch Institute
- Sébastien Calvignac-Spencer
- Robert Koch Institute
- Fabian H. Leendertz
- Robert Koch Institute
- George M. Shaw
- Department of Medicine, University of Pennsylvania
- Beatrice H. Hahn
- Department of Medicine, University of Pennsylvania
- Paul M. Sharp
- Institute of Evolutionary Biology and Centre for Immunity, Infection and Evolution, University of Edinburgh
- DOI
- https://doi.org/10.1038/s41467-022-29306-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Plasmodium malariae is a cause of malaria in humans and related species have been identified in non-human primates. Here, the authors use genomic analyses to establish that human P. malariae arose from a host switch of an ape parasite whilst a species infecting New World monkeys can be traced to a reverse zoonosis.
