Nature Communications (Jan 2017)
CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1
- Tongzheng Liu,
- Jia Yu,
- Min Deng,
- Yujiao Yin,
- Haoxing Zhang,
- Kuntian Luo,
- Bo Qin,
- Yunhui Li,
- Chenming Wu,
- Tao Ren,
- Yang Han,
- Peng Yin,
- JungJin Kim,
- SeungBaek Lee,
- Jing Lin,
- Lizhi Zhang,
- Jun Zhang,
- Somaira Nowsheen,
- Liewei Wang,
- Judy Boughey,
- Matthew P. Goetz,
- Jian Yuan,
- Zhenkun Lou
Affiliations
- Tongzheng Liu
- Jinan University Institute of Tumor Pharmacology
- Jia Yu
- Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic
- Min Deng
- Department of Oncology, Mayo Clinic
- Yujiao Yin
- Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine
- Haoxing Zhang
- School of Life Sciences, Southwest University
- Kuntian Luo
- Department of Oncology, Mayo Clinic
- Bo Qin
- Department of Oncology, Mayo Clinic
- Yunhui Li
- Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine
- Chenming Wu
- Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine
- Tao Ren
- Department of Respiratory Medicine, East Hospital, Tongji University School of Medicine
- Yang Han
- Department of Pathology, East Hospital, Tongji University School of Medicine
- Peng Yin
- Department of Immunology, Mayo Clinic
- JungJin Kim
- Department of Oncology, Mayo Clinic
- SeungBaek Lee
- Department of Oncology, Mayo Clinic
- Jing Lin
- First Affiliated Hospital, Chinese PLA General Hospital
- Lizhi Zhang
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Jun Zhang
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Somaira Nowsheen
- Medical Scientist Training Program, Mayo Medical School and Mayo Graduate School, Mayo Clinic
- Liewei Wang
- Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic
- Judy Boughey
- Division of Subspecialty General Surgery, Mayo Clinic
- Matthew P. Goetz
- Department of Oncology, Mayo Clinic
- Jian Yuan
- Department of Oncology, Mayo Clinic
- Zhenkun Lou
- Department of Oncology, Mayo Clinic
- DOI
- https://doi.org/10.1038/ncomms13923
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Overexpression of SNAIL confers tumour cells with cancer stem-like characteristics associated with tumour progression. Here the authors show that inhibition of CDK4/6 blocks tumour metastasis in triple negative breast cancer by targeting DUB3 which in turns deubiquitinates and stabilises SNAIL1.
