Acoustical Studies of Molecular Interactions in the Solution of Methyl Cobalamine Drug at Different Temperatures and Concentrations

Abstract

In the present study, ultrasonic velocity (U), density (ρ), and viscosity (η) have been measured at frequency 1 MHz in the binary mixtures of methyl cobalamine with water in the concentration range (0.1 to 0.0125%) at 303 K, 308 K, and 313 K using a multi-frequency ultrasonic interferometer. The measured values of density, ultrasonic velocity, and viscosity have been used to estimate the acoustical parameters, namely adiabatic compressibility (βa), relaxation time (τ), acoustic impedance (z), free length (Lf), free volume (Vf), internal pressure (Πi), and Wada’s constant (W). The obtained results support the complex formation, molecular association by intermolecular hydrogen bonding in the binary liquid mixtures.

Keywords

• methyl cobalamine
• free volume
• acoustical parameters
• ultrasonic velocity
• adiabatic compressibility
• acoustical impedance