The challenges and opportunities of scRNA-seq in COVID-19 research and clinical translation

Abstract

Abstract The application of single-cell RNA sequencing in COVID-19 research has greatly improved our understanding of COVID-19 pathogenesis and immunological characteristics. In this commentary, we discuss the current challenges, limitations, and perspectives in harnessing the power of single-cell RNA sequencing to accelerate both basic research and therapeutic development for COVID-19 and other emerging infectious diseases.

Keywords

• COVID-19
• SARS-CoV-2
• Single-cell RNA sequencing
• COVID-19 sequela
• Single-cell VDJ sequencing