Cerebral Venous Thrombosis in the Nephrotic Syndrome

Abstract

A 4-year-old boy with idiopathic steroid responsive nephritic syndrome developed bilateral sixth-nerve palsy and lethargy secondary to cerebral sinus thrombosis. Treatment with heparin, fresh frozen plasma as source of antithrombin III and vitamin K inhibitors may have prevented further sequels. However, anti-coagulation, as assessed by partial thromboplastin and prothrombin time, was difficult to achieve. Despite these problems the child made a complete neurological recovery.

Keywords

• Nephrotic syndrome
• Cerebral sinus thrombosis
• Anti-thrombin III deficiency.