Frontiers in Pediatrics (Aug 2022)

Case report: Experience of a rare case of rebound of the Kasabach-Merritt phenomenon during sirolimus treatment in kaposiform hemangioendothelioma

  • Liang Wang,
  • Jing Li,
  • Changhua Wu,
  • Dan Song,
  • Zhuang Liu,
  • Yanli Niu,
  • Jie Zhou,
  • Lei Guo,
  • Lei Guo,
  • Lei Guo

DOI
https://doi.org/10.3389/fped.2022.949950
Journal volume & issue
Vol. 10

Abstract

Read online

Kaposiform hemangioendothelioma (KHE) is a rare vascular neoplasm associated with the Kasabach–Merritt phenomenon (KMP), which is a consumptive coagulopathy with associated potentially life-threatening thrombocytopenia. There are no standardized treatment protocols for the management of KHE with KMP. Moreover, there are limited reports regarding the treatment of cases of rebound. Herein, we describe a rare case of rebound of KHE/KMP, during systemic sirolimus treatment, successfully treated with embolization and vincristine infusion combined with microwave ablation.

Keywords