Effect of Different Doses of Remifentanil on Hemodynamic Profiles and Intubation Conditions in Patients Undergoing Coronary Artery Bypass Graft Surgery, a Randomized Double-Blinded Placebo Controlled Trial

Abstract

Background: Hemodynamic instability is common during tracheal intubation. The primary purpose of the present study is to evaluate the effect of different doses of remifentanil added to propofol on the hemodynamic profiles during tracheal intubation. Methods: Ninety patients, 40 to 70 years old, undergoing coronary artery bypass graft surgery under general anesthesia were randomly allocated into control, low (2µg/kg) and high (4ug/kg) dose groups. Baseline heart rate (HR), mean arterial pressure (MAP) were recorded and documented again on intubation and 1, 2 and 4 minutes after intubation. Cough status before and after intubation was also recorded. Results: The basic characteristics of participants in all the three groups were similar. Heart rate and blood pressure decreased in all three groups after intubation. There was no difference in the intubation conditions and mask ventilation or coughing between the three groups. Conclusion: There was no significant difference observed between hemodynamic changes with high and low dose of remifentanil to attenuate the rise in MAP on intubation.

Keywords

• remifentanil
• tracheal intubation
• cardiovascular response