High-risk HLA alleles for severe acute graft-versus-host disease and mortality in unrelated donor bone marrow transplantation

Satoko Morishima; Koichi Kashiwase; Keitaro Matsuo; Fumihiro Azuma; Toshio Yabe; Aiko Sato-Otsubo; Seishi Ogawa; Takashi Shiina; Masahiro Satake; Hiroh Saji; Shunichi Kato; Yoshihisa Kodera; Takehiko Sasazuki; Yasuo Morishima

doi:10.3324/haematol.2015.136903

Haematologica (Apr 2016)

High-risk HLA alleles for severe acute graft-versus-host disease and mortality in unrelated donor bone marrow transplantation

Satoko Morishima,
Koichi Kashiwase,
Keitaro Matsuo,
Fumihiro Azuma,
Toshio Yabe,
Aiko Sato-Otsubo,
Seishi Ogawa,
Takashi Shiina,
Masahiro Satake,
Hiroh Saji,
Shunichi Kato,
Yoshihisa Kodera,
Takehiko Sasazuki,
Yasuo Morishima

Affiliations

Satoko Morishima: Department of Hematology, Fujita Health University School of Medicine, Toyoake, Aichi, Tokyo, Japan
Koichi Kashiwase: Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan
Keitaro Matsuo: Divsion of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan
Fumihiro Azuma: Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan
Toshio Yabe: Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan
Aiko Sato-Otsubo: Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Japan
Seishi Ogawa: Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Japan
Takashi Shiina: Division of Basic Medical Science and Molecular Medicine, Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
Masahiro Satake: Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan
Hiroh Saji: HLA Foundation Laboratory, Kyoto, Japan
Shunichi Kato: Department of Cell Transplantation and Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
Yoshihisa Kodera: Department of Promotion for Blood and Marrow Transplantation, Aichi Medical University School of Medicine, Nagakute, Japan
Takehiko Sasazuki: Institute for Advanced Study, Kyushu University, Fukuoka, Japan
Yasuo Morishima: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan

DOI: https://doi.org/10.3324/haematol.2015.136903
Journal volume & issue: Vol. 101, no. 4

Abstract

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HLA molecules play an important role for immunoreactivity in allogeneic hematopoietic stem cell transplantation. To elucidate the effect of specific HLA alleles on acute graft-versus-host disease, we conducted a retrospective analysis using 6967 Japanese patients transplanted with T-cell-replete marrow from an unrelated donor. Using unbiased searches of patient and donor HLA alleles, patient and/or donor HLA-B*51:01 (patient: HR, 1.37, P

Published in Haematologica

ISSN: 0390-6078 (Print); 1592-8721 (Online)
Publisher: Ferrata Storti Foundation
Country of publisher: Italy
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website: http://www.haematologica.org

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