Nature Communications (Oct 2017)
Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts
Abstract
There is a need for humanised grafts to treat patients with intestinal failure. Here, the authors generate intestinal grafts by recellularizing native intestinal matrix with human induced pluripotent stem cell-derived epithelium and human endothelium, and show nutrient absorption after transplantation in rats.