Chinese Medicine (Sep 2008)

Anti-inflammatory effects of <it>Radix Gentianae Macrophyllae </it>(<it>Qinjiao</it>), <it>Rhizoma Coptidis </it>(<it>Huanglian</it>) and <it>Citri Unshiu Pericarpium </it>(<it>Wenzhou migan</it>) in animal models

  • Cho Yong-Baik,
  • Han Chang-Kyun,
  • Yoo Hunseung,
  • Kim Ji-Hong,
  • Jeon Hyo,
  • Jung Kiwon,
  • Park Eun,
  • Rhee Hae,
  • Kim Kyoung,
  • Ryu Chun,
  • Yang Hyung,
  • Yoo Myung

DOI
https://doi.org/10.1186/1749-8546-3-10
Journal volume & issue
Vol. 3, no. 1
p. 10

Abstract

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Abstract Background KHU14, an ethanolic extract of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) was tested for its anti-inflammatory effects. Methods Three out of 20 herbs were found to have anti-inflammatory effects. The formulation of these herbs, i.e. KHU14 was tested for croton oil-induced ear edema, carrageenan-induced paw edema, acetic acid-induced capillary permeability, cotton pellet and delayed type hypersensitivity. Results KHU14 exhibited anti-inflammatory effects in animal models of acute and chronic inflammation. The anti-inflammatory activity of KHU14 observed was comparable to that of celecoxib. KHU14 inhibited the production of NO and PGE2 in LPS/IFN-gamma-stimulated peritoneal macrophages, and reduced edema and the amount of infiltrated cells in animal models. Conclusion KHU14 exhibited anti-inflammatory effects as demonstrated in typical immunological tests for anti-inflammation in vitro and in vivo.