Correlation of serum lipoprotein (a) levels with angiographic lesion severity in coronary artery disease

Abstract

Background: The several epidemiological and meta-analysis studies suggested that the elevated lipoprotein (a) (Lp(a)) level is associated to cause the coronary artery disease (CAD). However, the role of this pro-atherogenic Lp (a) in regulating the severity of angiographic lesions in CAD is poorly understood. This study aimed to estimate the serum Lp (a) level and find its correlation with angiographic lesion severity in subjects with CAD. Methods: In this cross-sectional study, a total of 107 subjects angiographic lesion severity was determined by SYNergy between percutaneous coronary interventions with TAXUS and cardiac surgery (SYNTAX) scoring system and grouped into mild (<22) and severe (≤22) based on the SYNTAX score. The serum Lp (a) concentration in subjects' serum was measured by immunoturbidimetric assay. Results: The median Lp (a) level of all subjects was found to be 14.8 mg/dL, it was higher in severe angiographic lesion group (18.9 mg/dL, interquartile range [IQR]: 12.3–24.4) when compared to mild group (13.7 mg/dL, IQR: 6.6–18.6). The Spearman correlation analysis revealed that the relationship between serum Lp (a) level and angiographic lesion severity in mild and severe subjects is not statistically significant except with the mild group female subjects. Conclusions: Overall, this study does not support the association of angiographic lesion severity with serum Lp (a) levels in CAD. To infer precisely, similar studies with more subjects are needed to confirm this study's findings.

Keywords

• angiographic lesion severity
• coronary artery disease
• lipoprotein (a)
• synergy between percutaneous coronary interventions with taxus and cardiac surgery score