Nature Communications (Aug 2018)

Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter

  • Do Hoon Kwon,
  • Ok Hyun Park,
  • Leehyeon Kim,
  • Yang Ouk Jung,
  • Yeonkyoung Park,
  • Hyeongseop Jeong,
  • Jaekyung Hyun,
  • Yoon Ki Kim,
  • Hyun Kyu Song

DOI
https://doi.org/10.1038/s41467-018-05825-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

Read online

The autophagy adapter p62/SQSTM1 plays a key role in selective autophagy and also recognizes N-end rule substrates. Here the authors provide molecular insights into p62 N-end rule substrate recognition by solving the structures of the p62 ZZ-domain in complex with various type 1 and type 2 degrons and also show the pH dependent oligomerization of p62.