Nature Communications (Dec 2022)

Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes

  • Dan Zhao,
  • Kerui Wu,
  • Sambad Sharma,
  • Fei Xing,
  • Shih-Ying Wu,
  • Abhishek Tyagi,
  • Ravindra Deshpande,
  • Ravi Singh,
  • Martin Wabitsch,
  • Yin-Yuan Mo,
  • Kounosuke Watabe

DOI
https://doi.org/10.1038/s41467-022-35305-2
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 15

Abstract

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The molecular mechanisms explaining racial disparity in breast cancer mortality are not completely elucidated. Here, the authors show that an African-associated SNP in American breast cancer patients, leads to higher levels of microRNA miR-1304-3p which promotes cancer by increasing lipids availability.