Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection

Tracy T. Chow; Xiaoyu Shi; Jen-Hsuan Wei; Juan Guan; Guido Stadler; Bo Huang; Elizabeth H. Blackburn

doi:10.1038/s41467-018-05840-y

Nature Communications (Sep 2018)

Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection

Tracy T. Chow,
Xiaoyu Shi,
Jen-Hsuan Wei,
Juan Guan,
Guido Stadler,
Bo Huang,
Elizabeth H. Blackburn

Affiliations

Tracy T. Chow: Department of Biochemistry and Biophysics, University of California, San Francisco
Xiaoyu Shi: Department of Pharmaceutical Chemistry, University of California, San Francisco
Jen-Hsuan Wei: Department of Biochemistry and Biophysics, University of California, San Francisco
Juan Guan: Department of Pharmaceutical Chemistry, University of California, San Francisco
Guido Stadler: Berkeley Lights Inc
Bo Huang: Department of Pharmaceutical Chemistry, University of California, San Francisco
Elizabeth H. Blackburn: Department of Biochemistry and Biophysics, University of California, San Francisco

DOI: https://doi.org/10.1038/s41467-018-05840-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Chromatin dynamics is thought to play an important role in the maintenance of telomeres, yet how has remained poorly understood. Here the authors locally enrich heterochromatin protein 1α (HP1α) at human telomeres to provide insights into the crosstalk between epigenetic regulations and structural dynamics at the telomeres.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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