ALTERED EXPRESSION OF CARBOHYDRATE DETERMINANTS OF THE MUCOUS MEMBRANE OF THE GLANDULAR ZONE OF THE HARD PALATE IN EXPERIMENTAL HYPOSALIVATION

Abstract

Moisturizing the oral mucosa in a state of rest is provided by the secret of small salivary glands. However, the influence of various factors may lead to a decrease in secretory activity of the salivary glands - hyposalivation. The probing of the mucous membrane of the hard palate with mannosospecific lectin concanavalin A during experimental hyposalivation determined an increase in the expression of carbohydrate determinants from the side of fibroblasts and collagen fibers of the own plate and an increase in the binding of the vascular basement membrane due to hyperhydration of the amorphous substance. The decrease in the intensity of the exposure of the migrative cells of the connective tissue indicates the tension of local immunity to the irritant action of the ether of methacrylic acid. On the part of the myoepithelial cells of the terminal organs and the duct system of the small salivary glands there is a decrease in the expression of carbohydrate determinants, which is due to a decrease in secretory activity of glandulocytes.

Keywords

• mucous membrane
• hard palate
• hyposalivation
• lectins