Genetic Variation in Metronidazole Metabolism and Oxidative Stress Pathways in Clinical Giardia lamblia Assemblage A and B Isolates [Corrigendum]

Abstract

Saghaug CS, Klotz C, Kallio JP, et al. Infect Drug Resist. 2019;12:1221–1235. The authors have advised NR-1 was used throughout the paper to denote the gene named in GiardiaDB as “Nitroreductase family protein fused to ferredoxin domain Fd-NR1” (DHA2_153380/GSB_153178), while in recent literature this is often denoted NR2/GlNR2. Likewise, NR-2 was used to denote the gene named in GiardiaDB as “Nitroreductase Fd-NR-2” (DHA2_22677/GSB_22677), while in recent literature this is often denoted NR1/GlNR1. The authors acknowledge that using the NR gene names as annotated in GiardiaDB may cause confusion and therefore, bring this to the attention of readers that more correctly what is named “NR-1” in the paper should be read as “NR-2”, and “NR-1” should be read as “NR-2”. The authors apologize for not having considered this issue in the original manuscript. Read the original article

Keywords

• drug metabolism
• resistance
• genetic analysis
• metronidazole genes
• ferredoxin
• genetic diversity