CLINICAL AND GENETIC PECULIARITIES OF ATRIAL FIBRILLATION

S. Y. Nikulina; V. A. Schulman; O. O. Kuznetsova; N. V. Aksjutina; P. A. Shesternja; A. A. Chernova; V. N. Maksimov; I. V. Kulikov; S. N. Ustinov; Y. L. Kazarinova; A. G. Romashchenko; M. I. Voevoda

doi:10.20996/1819-6446-2008-4-2-13-18

Рациональная фармакотерапия в кардиологии (Jan 2016)

CLINICAL AND GENETIC PECULIARITIES OF ATRIAL FIBRILLATION

S. Y. Nikulina,
V. A. Schulman,
O. O. Kuznetsova,
N. V. Aksjutina,
P. A. Shesternja,
A. A. Chernova,
V. N. Maksimov,
I. V. Kulikov,
S. N. Ustinov,
Y. L. Kazarinova,
A. G. Romashchenko,
M. I. Voevoda

Affiliations

S. Y. Nikulina: Krasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk
V. A. Schulman: Krasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk
O. O. Kuznetsova: Krasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk
N. V. Aksjutina: Krasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk
P. A. Shesternja: Krasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk
A. A. Chernova: Krasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk
V. N. Maksimov: Krasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk
I. V. Kulikov: Krasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk
S. N. Ustinov: Krasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk
Y. L. Kazarinova: Krasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk
A. G. Romashchenko: Krasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk
M. I. Voevoda: Krasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk

DOI: https://doi.org/10.20996/1819-6446-2008-4-2-13-18
Journal volume & issue: Vol. 4, no. 2
pp. 13 – 18

Abstract

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Aim. To study inheritance patterns of atrial fibrillation (AF) and association of primary and secondary AF with gene polymorphism of β1-adrenoreceptors.Material and methods. 103 probands with AF and their 301 relatives of I, II, III degrees (basic group) and 82 probands without heart diseases and their 163 relatives of I and II degrees (control group) were examined. Examination included evaluation of electrophysiological indicators of sinoatrial node, electrocardiogram monitoring, veloergometry, echocardiography as well as assessment of gene polymorphism of β1-adrenoretseptors.Results. Accumulation of AF in probands families was founded. Segregation analysis of idiopathic AF revealed autosomal-dominant type of its inheritance.Сonclusion. The heterozygote genotype of gene β1-adrenoretseptors Ser49Gly is one of genetic predictors of primary and secondary AF.

Published in Рациональная фармакотерапия в кардиологии

ISSN: 1819-6446 (Print); 2225-3653 (Online)
Publisher: Столичная издательская компания
Country of publisher: Russian Federation
LCC subjects: Medicine: Therapeutics. Pharmacology; Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.rpcardio.online/jour

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Abstract

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