Antibiofilm activity of Lamium album L. Extracts

Abstract

In this study, the antibiofilm activity of ethanol, acetone, and ethyl acetate extracts of Lamium album was evaluated against nine clinical strains from human wound swabs and two reference strains. The extracts of L. album exhibited significant antibiofilm activity. The extracts inhibited cell attachment and subsequent biofilm formation. The activity was dose-and strain-dependent, which was confirmed by fluorescence microscopy. The effects on mature biofilms were lower. In addition, the results showed a decrease in bacterial auto-aggregation in the presence of the extracts and no motility reduction. Phytochemical analysis and identification of functional groups by using Fourier Transform Infrared Spectroscopy were also performed. The results obtained in this study provide a basis for further research on this plant species.

Keywords

• biofilm
• antibiofilm activity
• auto-aggregation
• phytochemical analysis
• clinical bacteria strains
• lamium album