The possibility of using laser methods for the quality control of highly diluted liquid pharmaceuticals

Abstract

Processing of interferon gamma antibodies, which involves gradual reduction of the concentration, induces the formation of deuterium-stabilized giant heterophase clusters (GHCs) of water characterized by the specific size spectrum and kinetics of formation/decay. An investigation into the formation/decay kinetics of GHCs of water by a 2D light scattering method using topological descriptors allows distinction between various dilutions of protein nanoparticles, in particular interferon gamma antibodies, and similar dilutions of glycine buffer (control). The possibility of analytical control of highly diluted pharmaceuticals is currently under discussion. The method may therefore find potential applications in the manufacturing control of ultrahighly diluted pharmaceuticals and express quality analysis.

Keywords

• сверхвысокие разведения лекарственных средств
• антитела к интерферону-гамма
• гигантские гетерофазные кластеры воды
• рассеяние лазерного света
• highly diluted pharmaceuticals
• interferon gamma antibodies
• giant heterogeneous clusters of water
• laser light scattering