Protective effect of grapes polyphenol concentrate “Fenokor” in terms of hypoxic myocardial injury

Abstract

Polyphenols of grapes and their beneficial effects on human health have been known for a long time and still attract more and more research interest.The aim of the research was to reveal cardioprotective properties of polyphenols contained in grape concentrate “Fenokor” in terms of experimental histotoxic hypoxia.Materials and methods. The study was conducted on 21 adult male Wistar rats divided into 3 groups, 2 of which were administered CoCl2 aqueous solution in a dose of 60 mg/kg for 7 days intragastrically. The control group consisted of 5 intact animals. The rats of the second group (n = 8) after the introduction of the cobalt did not receive any treatment, the animals of the third group (n = 8) after the administration of cobalt chloride intragastrically, were given Fenokor aqueous solution at a dose of 2,5 ml/kg along with 0,05 ml of water orally. Morphological study was performed using light and electron microscopy. During the experiment the following biochemical parameters such as contents of malondialdehyde, oxidative modification of proteins were estimated.The results. The result of the influence of cobalt on the heart of animals in experiments is the development of severe cardiomyopathy that requires cardio-protection. Histological structure of myocardium observed in the second group of male rats after cobalt intoxication on the background of grape polyphenol concentrate generally reflected a tendency to minimize the damage extent which was manifested in the form of normalization of cell structures and muscle fibers.Application of Fenokor has demonstrated its antioxidant and cytoprotective properties, which contributed to myocardial structure preservation in rats exposed to histotoxic hypoxia.

Keywords

• полифенолы винограда
• миокард
• гипоксия
• кобальт
• крысы
• эксперимент