Investigating the Pharmacological Mechanisms of Total Flavonoids from <i>Eucommia ulmoides</i> Oliver Leaves for Ischemic Stroke Protection

Abstract

The aim of this study was to explore how the total flavonoids from Eucommia ulmoides leaves (EULs) regulate ischemia-induced nerve damage, as well as the protective effects mediated by oxidative stress. The cell survival rate was significantly improved compared to the ischemic group (p p VEGF increased (p ERK and CCND1 increased (p VEGF-related pathways. MCAO rat models indicated that the total flavonoids of EULs could reduce brain ischemia–reperfusion injury. In conclusion, this study demonstrates the potential mechanisms of the total flavonoids of EULs in treating ischemic stroke and their potential therapeutic effects in reducing ischemic injury, which provides useful information for ischemic stroke drug discovery.

Keywords

• ischemic stroke
• <i>Eucommia ulmoides</i> leaves
• flavonoid
• oxidative stress
• network pharmacology