Integrated Blood Pressure Control (Apr 2022)
Serum Levels of NT-Pro BNP in Patients with Preeclampsia
Abstract
Thanh Xuan Nguyen,1 Van Tri Nguyen,2 Hong Ngoc Nguyen-Phan,3 Bui Bao Hoang3 1Department of Abdominal Emergency and Pediatric Surgery, Hue Central Hospital, Hue City, 530000, Vietnam; 2Department of Anesthesiology, Hue International Medical Center, Hue Central Hospital, Hue City, 530000, Vietnam; 3Department of Internal Medicine, Hue University of Medicine and Pharmacy, Hue University, Hue City, 530000, VietnamCorrespondence: Bui Bao Hoang, Department of Internal Medicine, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen Street, Hue City, Vietnam, Tel +84 905405005, Email [email protected]; [email protected]: This study aims to determine the serum levels of NT-proBNP in women with preeclampsia with and without severe signs and to evaluate the cardiovascular risks in these two groups of participants.Methods: A descriptive cross-sectional study was conducted on 52 women with preeclampsia in the Department of Gynecology and Obstetrics – Hue Central Hospital, from August 2019 to September 2020.Results: In preeclampsia women, the rate of hypertension in stage 3, stage 2, and stage 1 were 46.1%, 32.7%, and 21.2%, respectively. The average Sokolow-Lyon index in the preeclampsia group with and without severe signs was 22.25 ± 7.38mm, 20.16 ± 5.54mm, respectively. The average left ventricular mass index in the group of preeclampsia patients without and with severe signs was 92.27 ± 14.56g/m2 and 120.68 ± 16.47g/m2, respectively. The average ejection fraction in the group of preeclampsia patients without severe signs and with severe signs was 65.11 ± 3.45%, 56.21 ± 7.12%, correspondingly. In contrast, the difference between the two groups was statistically significant with p < 0.05. The plasma NT-proBNP level in the preeclampsia group without severe signs was 349.12 ± 93.51pg/mL, whereas the concentration in the preeclampsia group with severe signs was 725.32 ± 290.46pg/mL (p < 0.05).Conclusion: The NT-proBNP level was statistically significantly increased in the patients with preeclampsia. Analyzing and comparing the figures and changes found in two groups of PE patients, with and without severe signs, we suggest that women diagnosed with PE with severe signs have a higher risk of developing cardiovascular problems forthwith and henceforth.Keywords: preeclampsia, cardiovascular, NT-proBNP
