Molecules (Jan 2021)

Selina-1,3,7(11)-trien-8-one and Oxidoselina-1,3,7(11)-trien-8-one from <i>Eugenia uniflora</i> Leaf Essential Oil and Their Cytotoxic Effects on Human Cell Lines

  • Jociani Ascari,
  • Marcos Felipe Maciel Pereira,
  • Vinicius Monteiro Schaffka,
  • Domingos Sávio Nunes,
  • Cássia Gonçalves Magalhães,
  • Jânio Sousa Santos,
  • Daniel Granato,
  • Mariana Araújo Vieira do Carmo,
  • Luciana Azevedo,
  • Marcos Vinicio Lopes Rodrigues Archilha,
  • Dilamara Riva Scharf

DOI
https://doi.org/10.3390/molecules26030740
Journal volume & issue
Vol. 26, no. 3
p. 740

Abstract

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The sesquiterpenes selina-1,3,7(11)-trien-8-one and oxidoselina-1,3,7(11)-trien-8-one were isolated from the essential oil of Eugenia uniflora L. leaves. The structures were elucidated using spectrometric methods (UV, GC–MS, NMR, and specific optical rotation). The relationship between antioxidant activity, as determined by DPPH assay, and the cytotoxic effect was evaluated using tumor cells, namely lung adenocarcinoma epithelial cells (A549) and human hepatoma carcinoma cells (HepG2), as well as a model of normal human lung fibroblast cells (IMR90). Both compounds did not show prominent free-radical scavenging activity according to DPPH assay, and did not inhibit lipid peroxidation in Wistar rat brain homogenate. The isolated compounds showed pro-oxidative effects and cytotoxicity in relation to the IMR90 cell line.

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