NLR, CRP, LDH as severity markers in Coronavirus Positive patients

Abstract

Background: Coronavirus is a deadly respiratory virus and was discovered way back in 1965 but made a recent comeback in November- December 2019. In March 2020, coronavirus infection was declared a pandemic, since then there has been widespread research taking place on this virus. For confirmatory diagnosis of coronavirus infection, Rapid Antigen detection test, TRUNAAT, RTPCR are used. Aim: Correlation of NLR, CRP, LDH as a marker of severity, morbidity, and mortality of coronavirus positive patients. Discussion: Coronavirus has undergone multiple small changes in its RNA genome known as mutation leading to production of variants. A lot of variants have been produced and detected since then because of its high replicability and mutation rate. The more dangerous variants have been labelled as Variants of Concern and less severe variants have also been detected which are known as Variants of Interest. Although, a viral infection is usually associated with lymphocytosis in most cases, but coronavirus infection has been reported to be associated with lymphopenia. Conclusion: There is a significant correlation of Neutrophil to Lymphocyte Ratio, S.CRP, S.LDH with the severity of coronavirus disease. They can be used individually as well as in combination as markers to establish severity of the coronavirus disease and helps in deciding prognosis of the patient.

Keywords

• nlr
• coronavirus
• severity marker
• crp
• ldh