Nature Communications (Aug 2021)

Microbial production of megadalton titin yields fibers with advantageous mechanical properties

  • Christopher H. Bowen,
  • Cameron J. Sargent,
  • Ao Wang,
  • Yaguang Zhu,
  • Xinyuan Chang,
  • Jingyao Li,
  • Xinyue Mu,
  • Jonathan M. Galazka,
  • Young-Shin Jun,
  • Sinan Keten,
  • Fuzhong Zhang

DOI
https://doi.org/10.1038/s41467-021-25360-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Here, the authors engineer microbial production of muscle titin fibers with highly desirable mechanical properties and provide structural analyses that explain the molecular mechanisms underlying high performance of this polymer with potential uses in biomedicine and textile industries, among others.