Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation

Ines Martinez-Corral; Yan Zhang; Milena Petkova; Henrik Ortsäter; Sofie Sjöberg; Sandra D. Castillo; Pascal Brouillard; Louis Libbrecht; Dieter Saur; Mariona Graupera; Kari Alitalo; Laurence Boon; Miikka Vikkula; Taija Mäkinen

doi:10.1038/s41467-020-16496-y

Nature Communications (Jun 2020)

Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation

Ines Martinez-Corral,
Yan Zhang,
Milena Petkova,
Henrik Ortsäter,
Sofie Sjöberg,
Sandra D. Castillo,
Pascal Brouillard,
Louis Libbrecht,
Dieter Saur,
Mariona Graupera,
Kari Alitalo,
Laurence Boon,
Miikka Vikkula,
Taija Mäkinen

Affiliations

Ines Martinez-Corral: Uppsala University, Department of Immunology, Genetics and Pathology
Yan Zhang: Uppsala University, Department of Immunology, Genetics and Pathology
Milena Petkova: Uppsala University, Department of Immunology, Genetics and Pathology
Henrik Ortsäter: Uppsala University, Department of Immunology, Genetics and Pathology
Sofie Sjöberg: Uppsala University, Department of Immunology, Genetics and Pathology
Sandra D. Castillo: Vascular Signaling Laboratory, Institut d´Investigació Biomèdica de Bellvitge (IDIBELL), 08908L´Hospitalet de Llobregat
Pascal Brouillard: Human Molecular Genetics, de Duve Institute, University of Louvain
Louis Libbrecht: Center for Vascular Anomalies, Division of Pathology, Cliniques universitaires Saint Luc, University of Louvain
Dieter Saur: Department of Internal Medicine 2, Klinikum rechts der Isar, Technische Universität München
Mariona Graupera: Vascular Signaling Laboratory, Institut d´Investigació Biomèdica de Bellvitge (IDIBELL), 08908L´Hospitalet de Llobregat
Kari Alitalo: Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, FIN-00014 University of Helsinki
Laurence Boon: Human Molecular Genetics, de Duve Institute, University of Louvain
Miikka Vikkula: Human Molecular Genetics, de Duve Institute, University of Louvain
Taija Mäkinen: Uppsala University, Department of Immunology, Genetics and Pathology

DOI: https://doi.org/10.1038/s41467-020-16496-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Lymphatic malformation (LM) is a debilitating often incurable vascular disease. Using a mouse model of LM driven by a disease-causative PIK3CA mutation, the authors show that vascular growth is dependent on the upstream lymphangiogenic VEGF-C signalling, permitting effective therapeutic intervention.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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