International Journal of Molecular Sciences (Sep 2022)

The Microbiota–Gut–Brain Axis in Psychiatric Disorders

  • Aleksandra Góralczyk-Bińkowska,
  • Dagmara Szmajda-Krygier,
  • Elżbieta Kozłowska

DOI
https://doi.org/10.3390/ijms231911245
Journal volume & issue
Vol. 23, no. 19
p. 11245

Abstract

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Modulating the gut microbiome and its influence on human health is the subject of intense research. The gut microbiota could be associated not only with gastroenterological diseases but also with psychiatric disorders. The importance of factors such as stress, mode of delivery, the role of probiotics, circadian clock system, diet, and occupational and environmental exposure in the relationship between the gut microbiota and brain function through bidirectional communication, described as “the microbiome–gut–brain axis”, is especially underlined. In this review, we discuss the link between the intestinal microbiome and the brain and host response involving different pathways between the intestinal microbiota and the nervous system (e.g., neurotransmitters, endocrine system, immunological mechanisms, or bacterial metabolites). We review the microbiota alterations and their results in the development of psychiatric disorders, including major depressive disorder (MDD), schizophrenia (SCZ), bipolar disorder (BD), autism spectrum disorder (ASD), and attention-deficit hyperactivity disorder (ADHD).

Keywords