Materials (Nov 2022)

Synthesis, Characterization, DFT Study and Antifungal Activities of Some Novel 2-(Phenyldiazenyl)phenol Based Azo Dyes

  • Maria Marinescu,
  • Claudia Valentina Popa,
  • Maria Antonia Tănase,
  • Andreia Cristina Soare,
  • Cristina Tablet,
  • Daniela Bala,
  • Ludmila Otilia Cinteza,
  • Lia Mara Diţu,
  • Ioana Catalina Gifu,
  • Cristian Petcu

DOI
https://doi.org/10.3390/ma15228162
Journal volume & issue
Vol. 15, no. 22
p. 8162

Abstract

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In recent decades, there has been an increased interest in azo compounds with special optical and biological properties. In this work, we report the preparation of novel azo-compounds with two and three –N=N- double bonds, using the classical method of synthesis, diazotization and coupling. The compounds were characterized by 1H-NMR, 13C-NMR, FTIR, UV-VIS and fluorescence spectra. DFT calculations were employed for determining the optical parameters, polarizability α, the total static dipole moment μtot, the quadrupole moment Q and the mean first polarizability βtot. All azo derivatives show strong fluorescence emission in solutions. The antioxidant and antifungal activities were determined and the influence of the number of azo bonds was discussed. The synthesized compounds exhibit remarkable efficiency in the growth reduction of standard and clinical isolated Candida strains, suggesting future applications as novel antifungal.

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