Serum ferritin as a risk factor for type 2 diabetes mellitus, regulated by liver transferrin receptor 2

Rui Zhang; Xinmei Huang; Yue Li; Zhiyan Yu; Yueyue Wu; Bingbing Zha; Heyuan Ding; Shufei Zang; Jun Liu

doi:10.1530/EC-21-0316

Endocrine Connections (Dec 2021)

Serum ferritin as a risk factor for type 2 diabetes mellitus, regulated by liver transferrin receptor 2

Rui Zhang,
Xinmei Huang,
Yue Li,
Zhiyan Yu,
Yueyue Wu,
Bingbing Zha,
Heyuan Ding,
Shufei Zang,
Jun Liu

Affiliations

Rui Zhang: Department of Endocrinology, Shanghai Fifth People’s Hospital affiliated to Fudan University, Minhang District, Shanghai, People’s Republic of China
Xinmei Huang: Department of Endocrinology, Shanghai Fifth People’s Hospital affiliated to Fudan University, Minhang District, Shanghai, People’s Republic of China
Yue Li: Department of Endocrinology, Shanghai Fifth People’s Hospital affiliated to Fudan University, Minhang District, Shanghai, People’s Republic of China
Zhiyan Yu: Department of Endocrinology, Shanghai Fifth People’s Hospital affiliated to Fudan University, Minhang District, Shanghai, People’s Republic of China
Yueyue Wu: Department of Endocrinology, Shanghai Fifth People’s Hospital affiliated to Fudan University, Minhang District, Shanghai, People’s Republic of China
Bingbing Zha: Department of Endocrinology, Shanghai Fifth People’s Hospital affiliated to Fudan University, Minhang District, Shanghai, People’s Republic of China
Heyuan Ding: Department of Endocrinology, Shanghai Fifth People’s Hospital affiliated to Fudan University, Minhang District, Shanghai, People’s Republic of China
Shufei Zang: Department of Endocrinology, Shanghai Fifth People’s Hospital affiliated to Fudan University, Minhang District, Shanghai, People’s Republic of China
Jun Liu: Department of Endocrinology, Shanghai Fifth People’s Hospital affiliated to Fudan University, Minhang District, Shanghai, People’s Republic of China

DOI: https://doi.org/10.1530/EC-21-0316
Journal volume & issue: Vol. 10, no. 12
pp. 1513 – 1521

Abstract

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Objective: The aim of this study was to evaluate the effect of TFR2 on iron storage in type 2 diabetes. Methods: A cross-sectional study was conducted among 1938 participants f rom the Jiangchuan Community of Shanghai. A total of 784 participants w ith T2DM and 1154 normal participants (non-T2DM) were enrolled in this study. Ser um ferritin, fasting blood glucose, postprandial blood glucose, and HbA1C (glycated hemogl obin A1c) levels were determined. Eighteen Wistar male rats were randomly assigned in to three groups (n = 6/group): rats in a high-fat diet streptozotocin (HFD+STZ) group were fed with HFD for 4 weeks and intraperitoneally injected with streptozoto cin (STZ); rats in a control group were fed with a standard diet for 4 weeks and int raperitoneally injected with buffer; rats in an STZ group were fed with a standard diet for 4 weeks and intraperitoneally injected with streptozotocin. Glucose tolerance test was performed at the end of the study. Blood samples and liver tissues were asse ssed for liver TFR2, blood glucose, serum ferritin, and iron levels. Results: The mean serum ferritin level of T2DM participants was significa ntly higher than that of the control group (227 (140–352) vs 203.5 (130.5–312) n g/mL, P < 0.05). Serum ferritin level was an independent risk factor for T2DM (high fe rritin group vs low ferritin group, 1.304 (1.03–1.651), P < 0.05). Diabetic rats showed reduced liver TFR2 levels, with increased serum ferritin levels. Conclusion: T2DM participants exhibited iron disorder with elevated serum f erritin levels. Elevated serum ferritin levels in diabetic rats were accompanie d by reduced liver TFR2 levels.

Published in Endocrine Connections

ISSN: 2049-3614 (Online)
Publisher: Bioscientifica
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: http://www.endocrineconnections.com/

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