Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm

Hongwu Qian; Pingping Cao; Miaohui Hu; Shuai Gao; Nieng Yan; Xin Gong

doi:10.1038/s41467-019-10234-9

Nature Communications (May 2019)

Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm

Hongwu Qian,
Pingping Cao,
Miaohui Hu,
Shuai Gao,
Nieng Yan,
Xin Gong

Affiliations

Hongwu Qian: Department of Molecular Biology, Princeton University
Pingping Cao: State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences and School of Medicine, Tsinghua University
Miaohui Hu: Department of Molecular Biology, Princeton University
Shuai Gao: Department of Molecular Biology, Princeton University
Nieng Yan: Department of Molecular Biology, Princeton University
Xin Gong: Department of Molecular Biology, Princeton University

DOI: https://doi.org/10.1038/s41467-019-10234-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

Read online

Hedgehog (Hh) controls embryonic development via interaction with its receptor Patched (Ptch). Here the authors report the cryo-EM structure of tetrameric Ptch1 in complex with the palmitoylated N-terminal signaling domain of human Sonic hedgehog (ShhNp) at a 4:2 stoichiometric ratio.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal