Nature Communications (Sep 2021)
Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5
- Simon Schroeder,
- Christin Mache,
- Hannah Kleine-Weber,
- Victor M. Corman,
- Doreen Muth,
- Anja Richter,
- Diana Fatykhova,
- Ziad A. Memish,
- Megan L. Stanifer,
- Steeve Boulant,
- Mitra Gultom,
- Ronald Dijkman,
- Stephan Eggeling,
- Andreas Hocke,
- Stefan Hippenstiel,
- Volker Thiel,
- Stefan Pöhlmann,
- Thorsten Wolff,
- Marcel A. Müller,
- Christian Drosten
Affiliations
- Simon Schroeder
- Institute of Virology, Charité-Universitätsmedizin Berlin
- Christin Mache
- Unit 17, Influenza and other Respiratory Viruses, Robert Koch Institut
- Hannah Kleine-Weber
- Infection Biology Unit, German Primate Center – Leibniz Institute for Primate Research
- Victor M. Corman
- Institute of Virology, Charité-Universitätsmedizin Berlin
- Doreen Muth
- Institute of Virology, Charité-Universitätsmedizin Berlin
- Anja Richter
- Institute of Virology, Charité-Universitätsmedizin Berlin
- Diana Fatykhova
- Dept. of Infectious and Respiratory Diseases, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Ziad A. Memish
- Research and Innovation Department, King Saud Medical City, Ministry of Health
- Megan L. Stanifer
- Department of Infectious Diseases, Molecular Virology, Heidelberg University Hospital
- Steeve Boulant
- Research Group “Cellular polarity and viral infection”, German Cancer Research Center (DKFZ)
- Mitra Gultom
- Institute of Virology and Immunology (IVI)
- Ronald Dijkman
- Institute of Virology and Immunology (IVI)
- Stephan Eggeling
- Department of Thoracic Surgery, Vivantes Clinics Neukölln
- Andreas Hocke
- Dept. of Infectious and Respiratory Diseases, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Stefan Hippenstiel
- Dept. of Infectious and Respiratory Diseases, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Volker Thiel
- Institute of Virology and Immunology (IVI)
- Stefan Pöhlmann
- Infection Biology Unit, German Primate Center – Leibniz Institute for Primate Research
- Thorsten Wolff
- Unit 17, Influenza and other Respiratory Viruses, Robert Koch Institut
- Marcel A. Müller
- Institute of Virology, Charité-Universitätsmedizin Berlin
- Christian Drosten
- Institute of Virology, Charité-Universitätsmedizin Berlin
- DOI
- https://doi.org/10.1038/s41467-021-25519-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
MERS-CoV is enzootic in dromedary camels, can spread to humans but undergoes limited onward transmission. Here, Schroeder et al. compare clinical isolates of MERS-CoV in vitro and show that the predominantly circulating recombinant lineage 5 possess a fitness advantage over parental lineage 3 and 4 due to reduced activation of innate immune signaling.
