SARS-CoV-2: The Self-Nonself Issue and Diagnostic Tests

Abstract

Objective At present, false negatives/positives have been reported in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostics. Searching for the molecular basis of such tests' unreliability, this study aimed at defining how specific are the sequences used in serological and polymerase chain reaction (PCR) tests to detect SARS-CoV-2.

Keywords

• SARS-CoV-2 spike gp
• self-nonself
• serological tests
• PCR tests
• false positives