Communications Biology (Nov 2022)
Extra-hematopoietic immunomodulatory role of the guanine-exchange factor DOCK2
- Cornelia Scharler,
- Rodolphe Poupardin,
- Patricia Ebner-Peking,
- Martin Wolf,
- Christina Schreck,
- Gabriele Brachtl,
- Andre Cronemberger Andrade,
- Linda Krisch,
- Laurence Daheron,
- Katharina Schallmoser,
- Karsten Jürchott,
- Judit Küchler,
- Harald Stachelscheid,
- Hans-Dieter Volk,
- Robert A. J. Oostendorp,
- Dirk Strunk
Affiliations
- Cornelia Scharler
- Cell Therapy Institute, Spinal Cord Injury and Tissue Regeneration Center (SCI-TReCS), Paracelsus Medical University (PMU)
- Rodolphe Poupardin
- Cell Therapy Institute, Spinal Cord Injury and Tissue Regeneration Center (SCI-TReCS), Paracelsus Medical University (PMU)
- Patricia Ebner-Peking
- Cell Therapy Institute, Spinal Cord Injury and Tissue Regeneration Center (SCI-TReCS), Paracelsus Medical University (PMU)
- Martin Wolf
- Cell Therapy Institute, Spinal Cord Injury and Tissue Regeneration Center (SCI-TReCS), Paracelsus Medical University (PMU)
- Christina Schreck
- Technical University of Munich, School of Medicine, Internal Medicine III
- Gabriele Brachtl
- Cell Therapy Institute, Spinal Cord Injury and Tissue Regeneration Center (SCI-TReCS), Paracelsus Medical University (PMU)
- Andre Cronemberger Andrade
- Cell Therapy Institute, Spinal Cord Injury and Tissue Regeneration Center (SCI-TReCS), Paracelsus Medical University (PMU)
- Linda Krisch
- Cell Therapy Institute, Spinal Cord Injury and Tissue Regeneration Center (SCI-TReCS), Paracelsus Medical University (PMU)
- Laurence Daheron
- HSCI iPS Core Facility, Harvard University
- Katharina Schallmoser
- Department of Transfusion Medicine and SCI-TReCS, PMU
- Karsten Jürchott
- BCRT & Institute of Medical Immunology, Charité - Universitätsmedizin Berlin
- Judit Küchler
- BCRT & Institute of Medical Immunology, Charité - Universitätsmedizin Berlin
- Harald Stachelscheid
- BCRT & Institute of Medical Immunology, Charité - Universitätsmedizin Berlin
- Hans-Dieter Volk
- BCRT & Institute of Medical Immunology, Charité - Universitätsmedizin Berlin
- Robert A. J. Oostendorp
- Technical University of Munich, School of Medicine, Internal Medicine III
- Dirk Strunk
- Cell Therapy Institute, Spinal Cord Injury and Tissue Regeneration Center (SCI-TReCS), Paracelsus Medical University (PMU)
- DOI
- https://doi.org/10.1038/s42003-022-04078-1
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 10
Abstract
The guanine exchange factor DOCK2 regulates the development of immunomodulatory function in human stromal cells (mesenchymal stem/progenitor cells (MSPC) and fibroblasts), as demonstrated in three models.
