Physiological and Molecular Function of the Sodium/Hydrogen Exchanger NHA2 (SLC9B2)

Tin Manh Ho; Stephan Berger; Philipp Müller; Céline Simonin; Jean-Louis Reymond; Christoph von Ballmoos; Daniel G. Fuster

doi:10.2533/chimia.2022.1019

CHIMIA (Dec 2022)

Physiological and Molecular Function of the Sodium/Hydrogen Exchanger NHA2 (SLC9B2)

Tin Manh Ho,
Stephan Berger,
Philipp Müller,
Céline Simonin,
Jean-Louis Reymond,
Christoph von Ballmoos,
Daniel G. Fuster

Affiliations

Tin Manh Ho: Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern
Stephan Berger: Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Switzerland
Philipp Müller: Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Switzerland
Céline Simonin: Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Switzerland
Jean-Louis Reymond: Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Switzerland
Christoph von Ballmoos: Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Switzerland
Daniel G. Fuster: Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern

DOI: https://doi.org/10.2533/chimia.2022.1019
Journal volume & issue: Vol. 76, no. 12

Abstract

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NHA2, also known as SLC9B2, is an orphan intracellular Na+/H+ exchanger (NHE) that has been associated with arterial hypertension and diabetes mellitus in humans. The objective of this NCCR TransCure project was to define the physiological and molecular function of NHA2, to develop a high resolution kinetic transport assay for NHA2 and to identify specific and potent compounds targeting NHA2. In this review, we summarize the results of this highly interdisciplinary and interfaculty effort, led by the groups of Proffs. Jean-Louis Reymond, Christoph von Ballmoos and Daniel Fuster.

Published in CHIMIA

ISSN: 0009-4293 (Print); 2673-2424 (Online)
Publisher: Swiss Chemical Society
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: http://chimia.ch

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