Nature Communications (Jul 2020)

Comprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution

  • Roxane M. Pommier,
  • Amélien Sanlaville,
  • Laurie Tonon,
  • Janice Kielbassa,
  • Emilie Thomas,
  • Anthony Ferrari,
  • Anne-Sophie Sertier,
  • Frédéric Hollande,
  • Pierre Martinez,
  • Agnès Tissier,
  • Anne-Pierre Morel,
  • Maria Ouzounova,
  • Alain Puisieux

DOI
https://doi.org/10.1038/s41467-020-17249-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Claudin-low tumors are a rare aggressive subtype of breast cancers. In this study, the authors use a multiomics approach to demonstrate that these tumors are heterogeneous and comprise three main subgroups that emerge from different evolutionary processes.