Signalling pathways in the osteogenic differentiation of periodontal ligament stem cells

Abstract

PDLSCs possess multidirectional differentiation potential and self-renewal ability. In the inflammatory environment, signalling pathways, such as Wnt/β-catenin, Wnt/Ca2+, Wnt/PCP, NF-κB, MAPK, BMPs, and PI3K/AKT, are involved in regulating the osteogenic differentiation of PDLSCs. In addition, multiple signalling pathways that interact with microRNAs play crucial roles in the osteogenic differentiation of PDLSCs.

Keywords

• inflammatory environment
• periodontal ligament stem cells
• osteogenic differentiation
• signalling pathways