Duloxetine hydrochloride induced syndrome of inappropriate antidiuretic hormone secretion in depression treatment： a case report

Abstract

Duloxetine hydrochloride，a serotonin-norepinephrine reuptake inhibitor （SNRIs）， is a commonly used antidepressants. Its mechanism of action involves increasing synaptic monoamine neurotransmitters concentration， leading to antidepressant effects. While gastrointestinal reactions and elevated blood pressure are common side effects， duloxetine can rarely induce syndrome of inappropriate antidiuretic hormone secretion （SIADH）. This case report presents a patient with depression who developed SIADH following duloxetine hydrochloride initiation， with the main clinical manifestation being restless thirst and excessive drinking. This case is presented to raise awareness among clinicians of this rare yet potentially serious adverse effect of duloxetine treatment.

Keywords

• duloxetine hydrochloride
• depression
• syndrome of inappropriate antidiuretic hormone secretion