Efficient Microwave-Assisted Synthesis of 5-Deazaflavine Derivatives

Abstract

A series of pyrimido[4,5-b]quinolines (5-deazaflavines), were synthesized by microwave assisted intramolecular cyclization. The N4-substituted-2,4-diamino-6-chloro-pyrimidine-5-carbaldehydes, were prepared by selective monoamination of 2-amino-4,6-dichloropyrimidine-5-carbaldehyde with aliphatic and aromatic amines.

Keywords

• pyrimidoquinolines
• cyclocondensation
• microwave
• deazaflavines