Toxicological Effects of Brodifacoum and Food Energy Inhibitor on Some Physiological Parameters in House Rats (Rattus rattus)

Abstract

This study was conducted to investigate the effects of two different rodenticides, i.e., brodifacoum (BRD) and food energy inhibitor (FEI) on some physiological parameters in house rats (Rattus rattus). A total of 42 rats were randomly divided into 3 equal groups. One group served as a control while other two groups were fed BRD and FEI. Results revealed that feed intake and body weights were significantly lower in FEI group as compared with the control group. However, liver, heart and kidney weights were significantly high in BRD group. Mean concentration of glucose and triiodothyronine (T3) concentrations were significantly low in BRD group, while alanine aminotransferase (ALT), aspartate aminotransferase (AST), thyroxine (T4), LDH (lactate dehydrogenase) and CK-MB (creatinine-kinase) concentrations were significantly high in the rats of BRD group. It was concluded from this study that BRD has significant toxic effect on physiological biochemistry of house rats as compared to FEI.

Keywords

• Brodifacoum
• Cellulose
• Food energy inhibitor
• House rats