IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development

Benyu Liu; Buqing Ye; Xiaoxiao Zhu; Guanling Huang; Liuliu Yang; Pingping Zhu; Ying Du; Jiayi Wu; Shu Meng; Yong Tian; Zusen Fan

doi:10.1038/s41467-017-00235-x

Nature Communications (Aug 2017)

IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development

Benyu Liu,
Buqing Ye,
Xiaoxiao Zhu,
Guanling Huang,
Liuliu Yang,
Pingping Zhu,
Ying Du,
Jiayi Wu,
Shu Meng,
Yong Tian,
Zusen Fan

Affiliations

Benyu Liu: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Buqing Ye: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Xiaoxiao Zhu: Key Laboratory of RNA Biology of CAS, Institute of Biophysics, Chinese Academy of Sciences
Guanling Huang: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Liuliu Yang: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Pingping Zhu: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Ying Du: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Jiayi Wu: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Shu Meng: Key Laboratory of RNA Biology of CAS, Institute of Biophysics, Chinese Academy of Sciences
Yong Tian: University of Chinese Academy of Sciences
Zusen Fan: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-017-00235-x
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Innate lymphoid cells (ILC) are important regulators of mucosal immunity, but how their development and homeostasis are modulated is still unclear. Here the authors show that the differentiation of group 3 ILCs is controlled by the glutamylation of IL-7Rα and the induction of transcription factor Sall3.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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