Natural Products Produced in Culture by Biosynthetically Talented <i>Salinispora arenicola</i> Strains Isolated from Northeastern and South Pacific Marine Sediments

David E. Williams; Kalindi D. Morgan; Doralyn S. Dalisay; Teatulohi Matainaho; Elodie Perrachon; Noemie Viller; Maïlys Delcroix; Jeanne Gauchot; Haruka Niikura; Brian O. Patrick; Katherine S. Ryan; Raymond J. Andersen

doi:10.3390/molecules27113569

Molecules (Jun 2022)

Natural Products Produced in Culture by Biosynthetically Talented <i>Salinispora arenicola</i> Strains Isolated from Northeastern and South Pacific Marine Sediments

David E. Williams,
Kalindi D. Morgan,
Doralyn S. Dalisay,
Teatulohi Matainaho,
Elodie Perrachon,
Noemie Viller,
Maïlys Delcroix,
Jeanne Gauchot,
Haruka Niikura,
Brian O. Patrick,
Katherine S. Ryan,
Raymond J. Andersen

Affiliations

David E. Williams: Departments of Chemistry and Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, BC V6T 1Z1, Canada
Kalindi D. Morgan: Departments of Chemistry and Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, BC V6T 1Z1, Canada
Doralyn S. Dalisay: Center for Chemical Biology and Biotechnology (C2B2), Department of Biology, College of Liberal Arts, Sciences and Education, University of San Agustin, Iloilo 5000, Philippines
Teatulohi Matainaho: School of Medicine and Health Sciences, University of Papua New Guinea, Boroko P.O. Box 5623, NCD, Papua New Guinea
Elodie Perrachon: Departments of Chemistry and Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, BC V6T 1Z1, Canada
Noemie Viller: Departments of Chemistry and Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, BC V6T 1Z1, Canada
Maïlys Delcroix: Departments of Chemistry and Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, BC V6T 1Z1, Canada
Jeanne Gauchot: Departments of Chemistry and Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, BC V6T 1Z1, Canada
Haruka Niikura: Department of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada
Brian O. Patrick: Department of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada
Katherine S. Ryan: Department of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada
Raymond J. Andersen: Departments of Chemistry and Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, BC V6T 1Z1, Canada

DOI: https://doi.org/10.3390/molecules27113569
Journal volume & issue: Vol. 27, no. 11
p. 3569

Abstract

Read online

Laboratory cultures of two ‘biosynthetically talented’ bacterial strains harvested from tropical and temperate Pacific Ocean sediment habitats were examined for the production of new natural products. Cultures of the tropical Salinispora arenicola strain RJA3005, harvested from a PNG marine sediment, produced salinorcinol (3) and salinacetamide (4), which had previously been reported as products of engineered and mutated strains of Amycolatopsis mediterranei, but had not been found before as natural products. An S. arenicola strain RJA4486, harvested from marine sediment collected in the temperate ocean waters off British Columbia, produced the new aminoquinone polyketide salinisporamine (5). Natural products 3, 4, and 5 are putative shunt products of the widely distributed rifamycin biosynthetic pathway.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

About the journal

Abstract

Keywords