Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5

Andrzej Harris; Manuel Wagner; Dijun Du; Stefanie Raschka; Lea-Marie Nentwig; Holger Gohlke; Sander H. J. Smits; Ben F. Luisi; Lutz Schmitt

doi:10.1038/s41467-021-25574-8

Nature Communications (Sep 2021)

Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5

Andrzej Harris,
Manuel Wagner,
Dijun Du,
Stefanie Raschka,
Lea-Marie Nentwig,
Holger Gohlke,
Sander H. J. Smits,
Ben F. Luisi,
Lutz Schmitt

Affiliations

Andrzej Harris: Department of Biochemistry, University of Cambridge
Manuel Wagner: Institute of Biochemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1
Dijun Du: Department of Biochemistry, University of Cambridge
Stefanie Raschka: Institute of Biochemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1
Lea-Marie Nentwig: Institute of Biochemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1
Holger Gohlke: Institute of Pharmaceutical and Medicinal Pharmacy, Heinrich Heine University Düsseldorf, Universitätsstraße 1
Sander H. J. Smits: Institute of Biochemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1
Ben F. Luisi: Department of Biochemistry, University of Cambridge
Lutz Schmitt: Institute of Biochemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1

DOI: https://doi.org/10.1038/s41467-021-25574-8
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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Pdr5 is an ABC transporter conferring multidrug resistance to pathogenic fungi. Here, structural analysis of Pdr5 provides insights into the transport mechanism featuring asymmetric movements of Pdr5 domain and enabling efflux of a broad spectrum of compounds.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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