Nature Communications (Aug 2020)
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine
- Luis Felipe Campesato,
- Sadna Budhu,
- Jeremy Tchaicha,
- Chien-Huan Weng,
- Mathieu Gigoux,
- Ivan Jose Cohen,
- David Redmond,
- Levi Mangarin,
- Stephane Pourpe,
- Cailian Liu,
- Roberta Zappasodi,
- Dmitriy Zamarin,
- Jill Cavanaugh,
- Alfredo C. Castro,
- Mark G. Manfredi,
- Karen McGovern,
- Taha Merghoub,
- Jedd D. Wolchok
Affiliations
- Luis Felipe Campesato
- Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center
- Sadna Budhu
- Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center
- Jeremy Tchaicha
- Ikena Oncology
- Chien-Huan Weng
- Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center
- Mathieu Gigoux
- Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center
- Ivan Jose Cohen
- Department of Neurology and Louis V. Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center
- David Redmond
- Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center
- Levi Mangarin
- Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center
- Stephane Pourpe
- Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center
- Cailian Liu
- Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center
- Roberta Zappasodi
- Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center
- Dmitriy Zamarin
- Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center
- Jill Cavanaugh
- Ikena Oncology
- Alfredo C. Castro
- Ikena Oncology
- Mark G. Manfredi
- Ikena Oncology
- Karen McGovern
- Ikena Oncology
- Taha Merghoub
- Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center
- Jedd D. Wolchok
- Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center
- DOI
- https://doi.org/10.1038/s41467-020-17750-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
The tryptophan metabolite kynurenine is an endogenous ligand of the aryl hydrocarbon receptor (AHR). Here, the authors show that AHR targeting in IDO/TDO-expressing tumours counteracts a regulatory T cell/macrophage suppressive axis and synergizes with immune checkpoint blockade to hinder tumour growth.
