REM sleep promotes experience-dependent dendritic spine elimination in the mouse cortex

Yanmei Zhou; Cora Sau Wan Lai; Yang Bai; Wei Li; Ruohe Zhao; Guang Yang; Marcos G. Frank; Wen-Biao Gan

doi:10.1038/s41467-020-18592-5

Nature Communications (Sep 2020)

REM sleep promotes experience-dependent dendritic spine elimination in the mouse cortex

Yanmei Zhou,
Cora Sau Wan Lai,
Yang Bai,
Wei Li,
Ruohe Zhao,
Guang Yang,
Marcos G. Frank,
Wen-Biao Gan

Affiliations

Yanmei Zhou: School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School
Cora Sau Wan Lai: School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam
Yang Bai: Shenzhen Bay Laboratory
Wei Li: School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University
Ruohe Zhao: School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School
Guang Yang: Department of Anesthesiology, Columbia University
Marcos G. Frank: College of Medical Sciences, Washington State University
Wen-Biao Gan: Skirball Institute, Department of Neuroscience and Physiology, Department of Anesthesiology, New York University School of Medicine

DOI: https://doi.org/10.1038/s41467-020-18592-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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Sleep plays an important role in learning and memory. Here the authors show that experience dependent elimination of spines is attenuated by REM sleep deprivation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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