Molecules (Sep 2013)

First Chemical Constituents from Cordia exaltata Lam and Antimicrobial Activity of Two Neolignans

  • Maria de Fátima Vanderlei de Souza,
  • Raimundo Braz Filho,
  • Rosangela do Socorro Ferreira Rodrigues Sarquis,
  • Milen Maria Magalhães de Souza Fernandes,
  • Fernando Antônio de Medeiros,
  • Jéssica Karina da Silva Maciel,
  • Fillipe de Oliveira Pereira,
  • Edeltrudes de Oliveira Lima,
  • Davi Antas e Silva,
  • Josean Fechine Tavares,
  • Raquel Bezerra de Sá de Sousa Nogueira,
  • Tiago Bezerra de Sá de Sousa Nogueira

DOI
https://doi.org/10.3390/molecules180911086
Journal volume & issue
Vol. 18, no. 9
pp. 11086 – 11099

Abstract

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The phytochemical study of Cordia exaltata Lam. (Boraginaceae) led to the isolation, through chromatographic techniques, of nineteen secondary metabolites: 8,8'dimethyl-3,4,3',4'-dimethylenedioxy-7-oxo-2,7'cyclolignan (1), 8,8'-dimethyl-4,5-dimethoxy-3',4'-methylenodioxy-7-oxo-2,7'cyclolignan (2), sitosterol (3a), stigmasterol (3b), sitosterol-3-O-β-d-glucopyranoside (4a), stigmasterol-3-O-β-d-glucopyranoside (4b), phaeophytin A (5), 132-hydroxyphaeophytin A (6), 173-ethoxypheophorbide A (7), 132-hydroxy-173-ethoxypheophorbide A (8), m-methoxy-p-hydroxybenzaldehyde (9), (E)-7-(3,4-dihydroxyphenyl)-7-propenoic acid (10), 1-benzopyran-2-one (11), 7-hydroxy-1-benzopyran-2-one (12), 2,5-bis-(3',4'-methylenedioxiphenyl)-3,4-dimethyltetrahydrofuran (13), 3,4,5,3',5'-pentamethoxy-1'-allyl-8.O.4'-neolignan (14), 3,5,7,3',4'-pentahydroxyflavonol (15), 5,7-dihydroxy-4'-methoxyflavone (16), 5,8-dihydroxy-7,4’-dimethoxyflavone (17), kaempherol 3-O-β-d-glucosyl-6''-α-L-ramnopyranoside (18) and kaempherol 3,7-di-O-α-l-ramnopyranoside (19). Their structures were identified by 1H and 13C-NMR using one and two-dimensional techniques. In addition, the antimicrobial activity of compounds 1, 2, 13 and 14 against bacteria and fungi are reported here for the first time.

Keywords